The original game was not too revealing about the Hojo and Lucrecia situation. I do not like Dirge of Cerberus very much because I believe the plot doesn't fit with the original. After all, it was not even written by the original Final Fantasy VII writers.
It does not matter what I say, because all of you are convinced that Hojo was a heartless psychopath with no character depth who did not care about Lucrecia or Sephiroth, even though I like to believe that he felt something for them, even if it was not traditional love.
Hojo was not a cruel serial killer. In the original game, all he did was shoot Vincent after he was cornered by him (he pulled at his hair which showed that he was frustrated) and he shot Gast after he ran off with a real Cetra. Even if Hojo had not come after him, Shinra would have caught up with Gast and taken Ifalna anyway. Didn't Hojo actually suggest that Gast return to Shinra before he shot him? I was only under the impression that he shot Gast once Gast refused to give up his Cetra woman. As for Sephiroth, I still have mixed feelings about that. All of you on here are making comments about how it was wrong for Hojo to infuse him with Jenova cells, that it would have been better for him to be normal. If he were normal, he would literally be no one. Just another average guy, probably with dark hair and weaker. The experiments made him great, just like parents who put pressure on their kids to be in sports. Only this is far more extreme that the super strict dad who puts his son through rigorous football training since age three.
The only other times that he is psychopathic is when he uses the Nibelheim survivors for his Jenova Reunion project and the fact that the tanks in the reactor were filled with innocent SOLDIERS and Hojo no doubt felt zero remorse for that. Oh, and the thing with Aerith but once she gets away he doesn't really bother with her or even Red XIII. He does not kill and torture for pleasure and psychopaths are usually not described as having depression and Hojo clearly appeared that way.