I know this is a pipe-dream, since it doesn't look like all the enemies have limb-targeting aspects, but I really hope they add some Vagrant Story to this and it's not just a basic 'you cut off an arm and it can't attack with that arm'. In Vagrant Story the limbs you targeted had an overall compounding effect on your opponent. Chip away at the legs and it's actions / movements were slower. Attack the arms and it's physical attacks would be weaker. Attack the head and it would stagger / reduce it's magical ability.
Really hoping it has at least a layer of that within this.
I get the feeling this is going to be for extra large sized enemies as a way of getting them to drop to the floor so you can fully attack them.