I'm surprised that Kabuto's the orphanage director...between him being in charge of an orphanage and Orochi basically chilling out while Yamato's keeping an eye on him, I kinda wonder how Konoha would have treated Mads if he had survived. (with him wandering around Konoha and shaking his cane at kids and yelling at them to get off his property?)
Sakura being away with Sasuke while pregnant explains why Naruto couldn't just explain to Sarada that he saw Sakura around while she was pregnant (and thus bypassing this whole who's Sarada's real mom drama) but oh man, I do love the idea of Karin and Sakura being friends in some way. (oh my god, Karin being an honorary aunt to Sarada would be amazing.)
Also, I just realized that why Sarada needs glasses still hasn't been explained, but I can accept that that she probably needs glasses for a mundane reason.
But that last page with the Uchiha family photo just gave me a lot of feels, I don't ship SasuSaku anymore, but, d'aaaw Sasuke has a little smile on his face.