Honestly, I believe there's too much time is being skipped from Ezio's time to Desmond's for him to get the third game. I think there might be one more significant character we'll be introduced to.
Third game as in the third numbered title. Altair was born in 1165, Ezio was born in 1459. That's just about 300 years. Flash forward another 300 years and you're in the late 1700s, which places us right in the middle of the American Revolution. I'm not so sure they're going skip all the secret society/Templar/Masonic associations with America. It would be pretty fucking corny, but I wouldn't be surprised if they take that direction.
Zealkin said:and I can only hope that she'll be awesome and be in the game
Sigh.
Oh well I'll try not to judge it too much until it's out. Needless to say I think there are very few Non-Americans out there that will actually like the fact that this is its setting. Let's hope they do it well enough.